解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Viral factor has been implicated in the etiopathogenesis of vitiligo. To elucidate the effects of viral double-stranded RNA (dsRNA) on melanocytes and to explore the underlying mechanisms, primary cultured normal human melanocytes were treated with synthetic viral dsRNA analog poly(I:C). The results demonstrated that ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2711
更新日期:2015-06-01 00:00:00
abstract::DNA repair is reduced in patients suffering from systemic lupus erythematosus (SLE), and it can induce the production of autoreactive antibodies due to the accumulation of DNA damage and nucleoprotein that produce immunogenic antigens. The accumulations of anti-Ku and DNA-PKcs antibodies, which are involved in nonhomo...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2465
更新日期:2015-05-01 00:00:00
abstract::Interferon gamma (IFN-γ) is one of the key cytokines that plays a major role against viral and intracellular bacterial infection. In addition to the IFN-γ gene, teleost fish possess a second copy known as IFN-γ-related (IFN-γrel) gene. This report describes structural and functional properties of IFN-γrel gene in the ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2656
更新日期:2015-05-01 00:00:00
abstract::RUNX2 is a member of the RUNX family of transcription factors, also containing the RUNX1 and RUNX3 proteins. These factors control the expression of genes essential for proper development in many cell lineages. RUNX2 plays a crucial role in the proliferation and differentiation of osteoblasts, required for bone format...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2014.2688
更新日期:2015-05-01 00:00:00
abstract::Sestrin2 is involved in a different cellular response to stress conditions. However, the function of Sestrin2 in the cardiovascular system remains unknown. In the present study, we tested whether Sestrin2 has a beneficial effect on macrophage cell apoptosis induced by oxidized low-density lipoprotein (oxLDL). We found...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2627
更新日期:2015-04-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcription factor residing in the cytoplasm in the resting cells. Upon stimulation, STAT3 is activated and translocated to the nucleus to regulate target genes. Although the canonical transcriptional function of STAT3 has been inte...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2713
更新日期:2015-04-01 00:00:00
abstract::Apoptotic endonuclease G (EndoG) is responsible for DNA fragmentation both during and after cell death. Previous studies demonstrated that genetic inactivation of EndoG is cytoprotective against various pro-apoptotic stimuli; however, specific inhibitors for EndoG are not available. In this study, we have developed a ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2530
更新日期:2015-02-01 00:00:00
abstract::Leber congenital amaurosis (LCA) causes severe visual impairment and blindness very early in life. Mutant alleles of several genes acting in different pathways, of which all have critical roles for normal retinal function, were involved in LCA development. The purpose of this study was to use genome-wide genotyping to...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2554
更新日期:2014-12-01 00:00:00
abstract::Disruption of cell-matrix interactions can lead to anoikis-apoptosis due to loss of matrix contacts. We previously showed that Nerve/glial antigen 2 (NG2) is a novel anoikis receptor. Specifically, overexpression of NG2 leads to anoikis propagation, whereas its suppression leads to anoikis attenuation. Interestingly, ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2014.2399
更新日期:2014-12-01 00:00:00
abstract::Protein homeostasis in the endoplasmic reticulum (ER) in eukaryotic cells is maintained by a conserved quality control system named ER-associated degradation (ERAD). The ERAD system retains misfolded or unassembled polypeptides in the ER, retrotranslocates them into the cytosol for degradation by the ubiquitin proteas...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2014.2452
更新日期:2014-08-01 00:00:00
abstract::Microsomal transfer protein (MTP), a lipid transfer protein localized in the endoplasmic reticulum of hepatocytes and enterocytes, plays an important role in the development of nonalcoholic fatty liver disease (NAFLD). Many existing studies have demonstrated that a common polymorphism (-493G>T, rs1800591 G>T) in the M...
journal_title:DNA and cell biology
pub_type: 杂志文章,meta分析
doi:10.1089/dna.2013.2238
更新日期:2014-06-01 00:00:00
abstract::Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodo...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2202
更新日期:2014-04-01 00:00:00
abstract::Exposure to microgravity is supposed to affect almost all biological systems, and we speculated that microgravity is potentially involved in autophagy regulation. A clinostat was used to simulate microgravity, and HEK293 cells that stably express GFP-LC3 were used for sensitive monitoring of autophagy induction. The c...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2089
更新日期:2014-03-01 00:00:00
abstract::ERGIC2 (formerly known as PTX1) is a gene identified by subtractive hybridization on the basis that it is expressed in normal human prostate, but not in prostate carcinoma. It is unrelated to the gene encoding pituitary homeobox protein (Ptx1 or Pitx1), which regulates pituitary hormone gene expression. Based on seque...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2225
更新日期:2014-02-01 00:00:00
abstract::The incidence of premature ovarian failure (POF), a condition causing amenorrhea and hypergonadotropic hypoestrogenism in women before the age of 40, has been increasing in recent years. As an irreversible pathological change, improved treatment strategies for this disease are urgently needed. In this study, a type of...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2032
更新日期:2013-12-01 00:00:00
abstract::KCNQ1 overlapping transcript 1 (KCNQ1OT1), a long noncoding RNA responsible for silencing a cluster of genes in cis, has been shown to be involved in multiple cancers. However, much remains unclear of how KCNQ1OT1 contributes to carcinogenesis. By thoroughly analyzing 510 hepatocellular carcinoma (HCC) cases and 1014 ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2118
更新日期:2013-11-01 00:00:00
abstract::Interleukin-6 (IL-6) signaling may play a causal role in the development of coronary heart disease. However, the relationship between IL-6 genotypes and plasma levels of IL-6 appears to be complex. To help clarify the inconsistent findings, we conducted a meta-analysis of the published genetic association studies of t...
journal_title:DNA and cell biology
pub_type: 杂志文章,meta分析
doi:10.1089/dna.2013.2148
更新日期:2013-11-01 00:00:00
abstract::Regenerative medicine is a new interdisciplinary field in biomedical science, which aims at the repair or replacement of the defective tissue or organ by congenital defects, age, injury, or disease. Various cell-related techniques such as stem cell-based biotherapy are a hot topic in the current press, and stem cell r...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2013.2104
更新日期:2013-10-01 00:00:00
abstract::There is strong evidence for the presence of a functional renin-angiotensin system in human adipose tissue. The aim of our study was to investigate the association of polymorphic variants of angiotensin-converting enzyme gene (ACE I/D) and angiotensin II type I receptor gene (AGTR1 A1166C) with extreme obesity and obe...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2014
更新日期:2013-08-01 00:00:00
abstract::Mitochondrial aldehyde dehydrogenase-2 (ALDH2) is the principal enzyme involved in alcohol metabolism in humans. Emerging evidence has shown that the common rs671 G>A (Glu504Lys) polymorphism in the ALDH2 gene might play a critical role in increasing the susceptibility to coronary heart disease (CHD), including myocar...
journal_title:DNA and cell biology
pub_type: 杂志文章,meta分析
doi:10.1089/dna.2013.1995
更新日期:2013-07-01 00:00:00
abstract::My 45 years of studying the molecular biology of adeno-associated virus are recounted. Additional activities as a mentor, department chair, and medical school administrator are described, as are my activities in the public sphere, which involved national issues related to science policy and medical education. ...
journal_title:DNA and cell biology
pub_type: 传,历史文章,杂志文章
doi:10.1089/dna.2013.2120
更新日期:2013-07-01 00:00:00
abstract::DNA methylation plays an essential role in carcinogenesis. Promoter hypermethylation can result in transcriptional silencing of specific genes, such as tumor suppressors. Thus far, few reports have investigated the effect of curcumin, an active component of the perennial herb Curcuma longa, on DNA methylation. In the ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2042
更新日期:2013-06-01 00:00:00
abstract::Host cell-derived danger-associated molecular patterns (DAMPs), such as the hemoglobin (Hb) can interact with the innate immune system either directly or through binding to pathogen-associated molecular patterns (PAMPs). Hemolysis occurs under various pathological conditions, leading to hemoglobinemia. In the extracel...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2012.1897
更新日期:2013-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associa...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2012.1836
更新日期:2013-01-01 00:00:00
abstract::Haplotypes formed by polymorphisms (T-786C, rs2070744; a variable number of tandem repeats in intron 4, and Glu298Asp, rs1799983) of the eNOS gene were associated previously with gestational hypertension (GH) and preeclampsia (PE). However, no study has explored the Tag SNPs rs743506 and rs7830 in these disorders. The...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2012.1768
更新日期:2012-12-01 00:00:00
abstract::Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to b...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/dna.2011.1565
更新日期:2012-10-01 00:00:00
abstract::Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of methylation of rep...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1537
更新日期:2012-10-01 00:00:00
abstract::Endothelin-converting enzyme-1 (ECE1) plays a key role in the development of a subset of neural crest lineages such as cardiogenesis. Genetic variants of ECE1 C338A (rs213045) and T839G (rs213046) have been shown to alter ECE1 expression. This observation led us to hypothesize that two polymorphisms might influence th...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2012.1626
更新日期:2012-08-01 00:00:00
abstract::We identified extracellular signal-regulated kinase 2 (erk2) from green mud crab, Scylla paramamosain, in this article. It was originally identified from an expressed sequence tag fragment from a normalized gonadal cDNA library. 5' Rapid amplification of cDNA end (RACE) technique was used to obtain the 5' untranslated...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1458
更新日期:2012-07-01 00:00:00
abstract::The development of the pancreas is a complicated process that is regulated on several levels. Pancreas transcription factor 1, alpha subunit (Ptf1a), also known as p48, is a pancreas-specific basic helix-loop-helix transcription factor that is critical for both exocrine pancreas development and maintenance of acinar c...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2012.1619
更新日期:2012-07-01 00:00:00
abstract::Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. Interleukin-2 (IL-2) plays a key role in the proliferation of T cells and natural killer cells. It has been reported that polymorphisms in the IL-2 gene are associated with various cancers. The aim of this study was to examine the effect o...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1603
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:This case-control study was conducted in order to evaluate the potential role of polymorphic genes encoding enzymes involved in estrogen biosynthesis (CYP19A1) and metabolism (GSTM1, GSTT1, and GSTP1), and their action in modulating individual susceptibility to breast cancer. METHODS:Genomic DNA was extracted ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1538
更新日期:2012-06-01 00:00:00
abstract::NANOG is a critical homeodomain transcription factor responsible for maintaining embryonic stem cell (ESC) self-renewal and pluripotency. In the present study, we isolated, sequenced, and characterized the NANOG gene in buffalo ESC-like cells. Here, we demonstrated that NANOG mRNA is expressed as multiple isoforms and...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1410
更新日期:2012-05-01 00:00:00
abstract::Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performe...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1416
更新日期:2012-05-01 00:00:00
abstract::The abnormal function of O(6)-methylguanine-DNA methyltransferase (MGMT) is reported to be associated with the occurrence of various tumors and malignant tumor progression. However, little evidence is available to describe its role in esophageal carcinogenesis. To address this issue, we constructed a stable MGMT-silen...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1318
更新日期:2012-05-01 00:00:00
abstract::The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1464
更新日期:2012-05-01 00:00:00
abstract::The epidermal growth factor (EGF) pathway stimulates proliferation and differentiation of epidermal and epithelial tissues, and plays an important role in tumorigenesis. The association between EGF polymorphisms and cancer risk is controversial; thus, we performed this meta-analysis. Overall, 41 case-control studies w...
journal_title:DNA and cell biology
pub_type: 杂志文章,meta分析
doi:10.1089/dna.2011.1394
更新日期:2012-04-01 00:00:00
abstract::Fibroblast growth factor 21 (FGF-21) is a novel regulator for metabolic syndrome (MetS), diabetes, and obesity. However, no study has been performed on the association of these diseases with FGF-21 gene polymorphism. The aim of the study was to investigate the association of 3' untranslated region (UTR) single-nucleot...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1302
更新日期:2012-04-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a disease with multifactorial etiology characterized by irreversible loss of central visual acuity. The discovery of susceptive single-nucleotide polymorphisms (SNPs) has progressed our understanding of AMD. Complement factor H (CFH) gene Y402H polymorphism and high-temperatur...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1214
更新日期:2012-03-01 00:00:00
abstract::Chlamydial infection of the lower genital tract usually spreads to the upper genital tract and is then responsible for more serious consequences, such as infertility, ectopic pregnancy, pelvic pain, and pelvic inflammatory disease. Genital infection with Chlamydia trachomatis and the resulting cytokine response largel...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1333
更新日期:2012-03-01 00:00:00